Hydrochloric Acid → HCID 136983845, compound

HRID 1507493Notes

Reaction equation

HRID 1507493 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]([NH:14][C:15]2[C:20]([C:21]3[S:22][C:23]4[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:24]=4[N:25]=3)=[C:19]([O:31]C)[N:18]=[C:17]([N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[N:16]=2)[CH2:9]1)=O)(C)(C)C.[ClH:39]>>[ClH:39].[F:30][C:27]1[CH:28]=[CH:29][C:23]2[S:22][C:21]([C:20]3[C:19](=[O:31])[NH:18][C:17]([N:33]4[CH2:38][CH2:37][O:36][CH2:35][CH2:34]4)=[N:16][C:15]=3[NH:14][C@@H:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)=[N:25][C:24]=2[CH:26]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 117677557HCID 117677557, compound

Product 1

HCID 136983845HCID 136983845, compound

Conditions

Temperature
80 °C

Procedure

To a 250 mL flask containing Compound 26 (255 mg, 0.469 mmol), hydrochloric acid, (37%, 7 ml) was added. This was then heated and stirred at 80° C. for approx 1 h. The reaction mixture was then concentrated to dryness to obtain the title compound.

Workup

  1. additionwas added
  2. temperatureThis was then heated
  3. concentrationThe reaction mixture was then concentrated to dryness

Sources & evidence

ORD record
ord-bf923004ce824aeab1803b514f07a9fb
Source dataset
uspto-grants-2015_12
Patent number
US09221809B2

Reaction notes

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