HCID 178506118, compound → 7-(Trifluoromethyl)benzo[d]thiazole

HRID 1507521Notes

Reaction equation

HRID 1507521 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[C:11]2[S:10][C:9](S)=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1>C(O)(=O)C.[Fe]>[F:14][C:2]([F:1])([F:13])[C:3]1[C:11]2[S:10][CH:9]=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 178506118HCID 178506118, compound

Product 1

HCID 233232027-(Trifluoromethyl)benzo[d]thiazoleYield 80.7%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Following the same procedure as in step 2 of Example 337 using 7-(trifluoromethyl)-1,3-benzothiazole-2-thiol (300 mg, 1.28 mmol, 1.00 equiv) and iron powder (710 mg, 10.00 equiv) in acetic acid (12.0 mL). 210 mg of the title compound was obtained as a crude product as a gray-white solid, which was used directly for next step without further purification.

Sources & evidence

ORD record
ord-e161881f33114723b24e920a8bf67fae
Source dataset
uspto-grants-2015_12
Patent number
US09221809B2

Reaction notes

Loading…