HCID 178527796, compound → 5-Chloro-1,3-benzothiazole

HRID 1507533Notes

Reaction equation

HRID 1507533 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](S)=[N:7][C:6]=2[CH:11]=1>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][CH:8]=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 1

HCID 178527796HCID 178527796, compound

Product 1

HCID 143885665-Chloro-1,3-benzothiazole

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Following the same procedure as in step 2 of Example 337 using 5-chloro-1,3-benzothiazole-2-thiol (1.0 g, 4.96 mmol, 1.00 equiv) and iron powder (2.8 g, 10.00 equiv) in acetic acid (15.0 mL). The crude product was purified through a silica gel column with ethyl acetate/petroleum ether (1:50-1:10) to afford the title compound as a white solid.

Workup

  1. customThe crude product was purified through a silica gel column with ethyl acetate/petroleum ether (1:50-1:10)

Sources & evidence

ORD record
ord-c8c0d597345448409d3788dce071d4c5
Source dataset
uspto-grants-2015_12
Patent number
US09221809B2

Reaction notes

Loading…