3-Chloropyridine-4-carboxylic acid → 3-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

HRID 1507572Notes

Reaction equation

HRID 1507572 reaction equation
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:23][CH2:22]2)=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:26])([CH3:25])[C:17](=[O:24])[N:18]2[CH:21]2[CH2:22][CH2:23]2)=[CH:14][CH:13]=1)=[O:6]

Participants

3

Reactant 2

HCID 27358163-Chloropyridine-4-carboxylic acidHCID 1184151856-Amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one

Product 1

HCID 734258273-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

Procedure

Prepared in analogy to example 26 from 3-chloroisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one (example 14c). The title compound was obtained as white foam.

Sources & evidence

ORD record
ord-a828bdbf0e664e8597a93931f2b5849f
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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