3-Chloropyridine-4-carboxylic acid → 3-Chloro-N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

HRID 1507579Notes

Reaction equation

HRID 1507579 reaction equation
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH2:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:25])([CH3:24])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[CH:20]=[C:19]2[C:15]([C:16]([CH3:24])([CH3:25])[C:17](=[O:23])[N:18]2[CH2:21][CH3:22])=[CH:14][CH:13]=1)=[O:6]

Participants

3

Reactant 2

HCID 27358163-Chloropyridine-4-carboxylic acidHCID 69068988HCID 69068988, compound2×

Product 1

HCID 734259473-Chloro-N-(1-ethyl-3,3-dimethyl-2-oxoindolin-6-yl)isonicotinamide

Procedure

Prepared in analogy to example 26 from 3-chloroisonicotinic acid and 6-amino-1-ethyl-3,3-dimethylindolin-2-one (G. Georges et al., US2006/142247 A1). The title compound was obtained as white solid.

Sources & evidence

ORD record
ord-faa9b535ab434aa99ad0492f80cd87f2
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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