HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 90046331, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Pyridine-4-carbonyl chloride | HCID 417436 | — |
| Reactant | HCID 90046302 | HCID 90046302 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 90046331 | HCID 90046331 | — |
Reaction Steps
A solution of 6-amino-1-(3-(cyclopropylthio)propyl)-3,3-dimethylindolin-2-one (160 mg, 496 μmol), isonicotinoyl chloride (84.2 mg, 595 μmol) and DIPEA (192 mg, 260 μl, 1.49 mmol) in dichloromethane (3 ml) was stirred at room temperature for 3 hours. The crude material was purified by flash chromatography on silica gel using EtOAc/heptane as eluent. The title compound was obtained as yellow viscous oil (131 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221816B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-244d7a2b439a4939ab71138e3bab83b9 |
| Source note | uspto-grants-2015_12 |