2-Chloroisonicotinic acid → 2-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)isonicotinamide

HRID 1507609Notes

Reaction equation

HRID 1507609 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:11][C:12]1[N:17]=[CH:16][C:15]2[C:18]([CH3:26])([CH3:25])[C:19](=[O:24])[N:20]([CH:21]3[CH2:23][CH2:22]3)[C:14]=2[CH:13]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:11][C:12]1[N:17]=[CH:16][C:15]2[C:18]([CH3:26])([CH3:25])[C:19](=[O:24])[N:20]([CH:21]3[CH2:22][CH2:23]3)[C:14]=2[CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 2369852-Chloroisonicotinic acidHCID 900475166-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

Product 1

HCID 734267522-Chloro-N-(1-cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)isonicotinamide

Procedure

Prepared in analogy to example 26 from 2-chloroisonicotinic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as light yellow foam.

Sources & evidence

ORD record
ord-a37e2190d6de4adcaf08fa4effeed29e
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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