2-(trifluoromethyl)pyrimidine-5-carboxylic Acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

HRID 1507615Notes

Reaction equation

HRID 1507615 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:11])=O)=[CH:5][N:4]=1.[NH2:14][C:15]1[N:20]=[CH:19][C:18]2[C:21]([CH3:29])([CH3:28])[C:22](=[O:27])[N:23]([CH:24]3[CH2:26][CH2:25]3)[C:17]=2[CH:16]=1>>[CH:24]1([N:23]2[C:17]3[CH:16]=[C:15]([NH:14][C:9]([C:6]4[CH:7]=[N:8][C:3]([C:2]([F:1])([F:13])[F:12])=[N:4][CH:5]=4)=[O:11])[N:20]=[CH:19][C:18]=3[C:21]([CH3:28])([CH3:29])[C:22]2=[O:27])[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 105838892-(trifluoromethyl)pyrimidine-5-carboxylic AcidHCID 900475166-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one

Product 1

HCID 73426552N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

Procedure

Prepared in analogy to example 26 from 2-(trifluoromethyl)pyrimidine-5-carboxylic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as off-white solid.

Sources & evidence

ORD record
ord-64e616fbccec4e4ba337ae91b44176b9
Source dataset
uspto-grants-2015_12
Patent number
US09221816B2

Reaction notes

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