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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1507615Generated: October 31, 2026

2-(trifluoromethyl)pyrimidine-5-carboxylic Acid → N-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-(trifluoromethyl)pyrimidine-5-carboxamide

https://huagongshe.com/reaction/1507615

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(trifluoromethyl)pyrimidine-5-carboxylic AcidHCID 10583889—
Reactant6-Amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-oneHCID 90047516—
ProductN-(1-Cyclopropyl-3,3-dimethyl-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-6-yl)-2-(trifluoromethyl)pyrimidine-5-carboxamideHCID 73426552—

Reaction Steps

Prepared in analogy to example 26 from 2-(trifluoromethyl)pyrimidine-5-carboxylic acid and 6-amino-1-cyclopropyl-3,3-dimethyl-1H-pyrrolo[3,2-c]pyridin-2(3H)-one (example 79c). The title compound was obtained as off-white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09221816B2
Source datasetuspto-grants-2015_12
ORD IDord-64e616fbccec4e4ba337ae91b44176b9
Source noteuspto-grants-2015_12