Hydrochloric Acid → HCID 47003147, compound

HRID 1507633Notes

Reaction equation

HRID 1507633 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][NH2:9])=[CH:4][CH:3]=1.Cl.[C:11]([OH:15])(=[O:14])[CH:12]=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]/[N:9]=[CH:12]/[C:11]([OH:15])=[O:14])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 760Glyoxylic AcidHCID 69982(4-Fluorophenyl)hydrazine

Product 1

HCID 47003147HCID 47003147, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 4-fluorophenyl hydrazine 1.32 g (0.011 mol) in water (30 mL) at room temperature was added HCl (1.32 g, 0.014 mol) followed by the drop-wise addition of glyoxylic acid (50%, 1.71 g, 0.012 mol) over 20 minutes. The thick suspension was stirred for 30 m. The product was isolated by filtration, washed with water and then dissolved in ethyl acetate (40 mL), dried over magnesium sulfate, filtered and the product isolated as a solid.

Workup

  1. customThe product was isolated by filtration
  2. washwashed with water
  3. dissolutiondissolved in ethyl acetate (40 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customthe product isolated as a solid

Sources & evidence

ORD record
ord-9e3f744ca1474d73b1bd06b6cbb4e298
Source dataset
uspto-grants-2015_12
Patent number
US09221805B2

Reaction notes

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