N-(4-fluorophenyl)-N-nitrosoglycine → HCID 178516722, compound

HRID 1507637Notes

Reaction equation

HRID 1507637 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([N:13]=[O:14])[CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1>C(OC(=O)C)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:9]=[C:10]([O-:12])[O+:14]=[N:13]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 86729695N-(4-fluorophenyl)-N-nitrosoglycine

Product 1

HCID 178516722HCID 178516722, compoundYield 106.6%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
70 °C

Procedure

N-(4-fluorophenyl)-N-nitrosoglycine (11.5 g, 54.7 mmol) was dissolved in acetic anhydride (100 mL) and heated to 70° C. for 14 h. The reaction mixture was cooled and then poured into ice water (300 mL) After for stirring for 30 m, the reaction mixture was filtered to provide 10.50 g (100%) of the title product.

Workup

  1. temperatureThe reaction mixture was cooled
  2. filtrationthe reaction mixture was filtered

Sources & evidence

ORD record
ord-b771a1d493a8425d875acc9a89b2f228
Source dataset
uspto-grants-2015_12
Patent number
US09221805B2

Reaction notes

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