4-Methoxyphenoxyacetic acid → 1-(4-(5-Amino-2-(4-(4-fluorophenyl)butyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-methoxyphenoxy)ethanone

HRID 1507850Notes

Reaction equation

HRID 1507850 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[S:13][C:14]3[N:15]=[C:16]([NH2:27])[N:17]=[C:18]([N:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[C:19]=3[N:20]=2)=[CH:4][CH:3]=1.[CH3:28][O:29][C:30]1[CH:40]=[CH:39][C:33]([O:34][CH2:35][C:36](O)=[O:37])=[CH:32][CH:31]=1>>[NH2:27][C:16]1[N:17]=[C:18]([N:21]2[CH2:22][CH2:23][N:24]([C:36](=[O:37])[CH2:35][O:34][C:33]3[CH:39]=[CH:40][C:30]([O:29][CH3:28])=[CH:31][CH:32]=3)[CH2:25][CH2:26]2)[C:19]2[N:20]=[C:12]([CH2:11][CH2:10][CH2:9][CH2:8][C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[S:13][C:14]=2[N:15]=1

Participants

3

Reactant 2

HCID 746494-Methoxyphenoxyacetic acidHCID 509421472-(4-(4-Fluorophenyl)butyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-amine

Product 1

HCID 667586931-(4-(5-Amino-2-(4-(4-fluorophenyl)butyl)thiazolo[5,4-d]pyrimidin-7-yl)piperazin-1-yl)-2-(4-methoxyphenoxy)ethanoneYield 35%

Procedure

This compound was prepared from 2-(4-(4-fluorophenyl)butyl)-7-(piperazin-1-yl)thiazolo[5,4-d]pyrimidin-5-amine using 4-methoxyphenoxyacetic acid in a yield of 35%, according to the procedure for the synthesis of example 50.

Workup

  1. customaccording to the procedure for the synthesis of example 50

Sources & evidence

ORD record
ord-24dcb404706b49228ac4d935e65429f7
Source dataset
uspto-grants-2015_12
Patent number
US09221822B2

Reaction notes

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