Methylamine → HCID 68291727, compound

HRID 1507945Notes

Reaction equation

HRID 1507945 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](Cl)=[C:8]([C:11]([NH2:13])=[O:12])[CH:7]=[N:6][N:5]2[CH:14]=1.[CH3:15][NH2:16]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([NH:16][CH3:15])=[C:8]([C:11]([NH2:13])=[O:12])[CH:7]=[N:6][N:5]2[CH:14]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 682911926-Bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carboxamide

Product 1

HCID 68291727HCID 68291727, compoundYield 98%

Procedure

A solution of 6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carboxamide (Preparation 5, 200 mg, 0.733 mmol), and methylamine (0.5 mL, 8M solution in EtOH) was heated to 80° C. for 1 hr in the CEM microwave. The reaction mixture was evaporated in vacuo to give the title compound (192 mg, 98%). HPLC (condition G): retention time=0.77 min. LCMS (condition B): m/z 269.0, 271.0.

Workup

  1. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-51776c526aec46d284ff4f7931120647
Source dataset
uspto-grants-2015_12
Patent number
US09221826B2

Reaction notes

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