Dichloromethane → HCID 90773835, compound

HRID 1508133Notes

Reaction equation

[CH3:1][C:2]1(C)[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][C:19]([C:22]#[N:23])=[CH:20][N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24](O)([CH3:26])[CH3:25])[N:9]=2)=[CH:4][CH2:3]1.[CH3:29][O:30][CH2:31][CH2:32][NH2:33].S(Cl)(Cl)=O.[CH2:38](Cl)Cl>>[CH3:38][CH:1]1[CH2:2][CH2:3][CH2:4][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][C:19]([C:22]#[N:23])=[CH:20][N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24]([NH:33][CH2:32][CH2:31][O:30][CH3:29])([CH3:25])[CH3:26])[N:9]=2)=[C:6]1[CH3:7]

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 80182-Methoxyethylamine

HCID 24386Thionyl Chloride

HCID 59457539HCID 59457539, compound

Product 1

HCID 90773835HCID 90773835, compound

Procedure

The title compound is prepared from 5-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-6-(1-hydroxy-1-methyl-ethyl)-pyridin-3-yl]-amide (as prepared in Example 59, step (e)), methoxyethylamine and thionyl chloride in DCM solvent according to the procedure in Example 14, step (e).

Sources & evidence

ORD record: ord-6212f2f91b3047cab710f6cbf2c5607a
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221797B2

Reaction notes

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