反应详情

A solution of 3-chloroisonicotinic acid (18.6 mmol) in 120 mL EtOH and 3 mL conc. H2SO4 was heated to reflux overnight. The mixture was concentrated in vacuo, redissolved in aq. NaHCO3 solution and extracted with EtOAc (2×). The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as yellow oil;

1. temperatureto reflux overnight
2. concentrationThe mixture was concentrated in vacuo
3. dissolutionredissolved in aq. NaHCO3 solution
4. extractionextracted with EtOAc (2×)
5. dry with materialThe combined organic layers were dried over MgSO4
6. concentrationconcentrated in vacuo