HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 3-chloroisonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 3-Chloropyridine-4-carboxylic acid | HCID 2735816 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | Ethyl 3-chloroisonicotinate | HCID 2762498 | — |
Reaction Steps
A solution of 3-chloroisonicotinic acid (18.6 mmol) in 120 mL EtOH and 3 mL conc. H2SO4 was heated to reflux overnight. The mixture was concentrated in vacuo, redissolved in aq. NaHCO3 solution and extracted with EtOAc (2×). The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as yellow oil;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221832B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-705167690877422d912cde74f65b8ce1 |
| Source note | uspto-grants-2015_12 |