反应详情

A suspension of 3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester (10 mmol) in 10 mL 25% HCl solution and 5 mL H2O was heated to reflux overnight. After cooling to RT, the reaction mixture was quenched with sat. aq. NaHCO3 solution and extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as brown solid;

1. temperaturewas heated
2. temperatureto reflux overnight
3. customthe reaction mixture was quenched with sat. aq. NaHCO3 solution
4. extractionextracted with EtOAc
5. dry with materialThe combined organic layers were dried over MgSO4
6. concentrationconcentrated in vacuo