HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylboronic acid → 3-Chloro-2-cyclopropylisonicotinic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | Ethyl 3-chloro-2-methylisonicotinate | HCID 86721905 | — |
| Product | 3-Chloro-2-cyclopropylisonicotinic acid ethyl ester | HCID 71239170 | — |
Reaction Steps
This compound was prepared using a method analogous to that of 3-chloro-2-methylisonicotinic acid ethyl ester (A.2.5.2), cyclopropylboronic acid replacing trimethylboroxine. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as colorless oil;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221832B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-5b296ee74e074b4b994864afebd20195 |
| Source note | uspto-grants-2015_12 |