Cyclopropylboronic acid → 3-Chloro-2-cyclopropylisonicotinic acid ethyl ester

HRID 1508207Notes

Reaction equation

HRID 1508207 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH3:11])[C:6]=1[Cl:12])[CH3:2].[CH:14]1(B(O)O)C[CH2:15]1>>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH:11]2[CH2:15][CH2:14]2)[C:6]=1[Cl:12])[CH3:2]

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 86721905Ethyl 3-chloro-2-methylisonicotinate

Product 1

HCID 712391703-Chloro-2-cyclopropylisonicotinic acid ethyl ester

Procedure

This compound was prepared using a method analogous to that of 3-chloro-2-methylisonicotinic acid ethyl ester (A.2.5.2), cyclopropylboronic acid replacing trimethylboroxine. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as colorless oil;

Workup

  1. customThis compound was prepared
  2. customPurification by CC (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-5b296ee74e074b4b994864afebd20195
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

Loading…