3-Chloro-2-cyclopropylisonicotinic acid ethyl ester → HCID 71239378, compound

HRID 1508208Notes

Reaction equation

HRID 1508208 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2N=[N:11][CH:12]=[CH:13][C:8]=2[C:7]=1[OH:15])=[O:5])[CH3:2].C(OC(=O)C1C=CN=[C:22]([CH:26]2[CH2:28][CH2:27]2)C=1Cl)C>>[CH2:1]([O:3][C:4]([C:6]1[O:14][C:9]2=[C:22]([CH:26]3[CH2:28][CH2:27]3)[N:11]=[CH:12][CH:13]=[C:8]2[C:7]=1[OH:15])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 712391703-Chloro-2-cyclopropylisonicotinic acid ethyl esterHCID 71239586HCID 71239586, compound

Product 1

HCID 71239378HCID 71239378, compound

Procedure

This compound was prepared using a method analogous to that of 5-hydroxyfuro[2,3-c]pyridazine-6-carboxylic acid ethyl ester (A.2.3.1), 3-chloro-2-cyclopropylisonicotinic acid ethyl ester replacing 3-chloropyridazine-4-carboxylic acid ethyl ester. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (7/3) gives the desired product as colorless oil;

Workup

  1. customThis compound was prepared
  2. customPurification by CC (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-978fe5da0c004bcd98c03a56076e574c
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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