furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime → 7-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

HRID 1508210Notes

Reaction equation

HRID 1508210 reaction equation
[CH3:1][O:2][N:3]=[C:4]1[C:12]2[CH:11]=[CH:10][N:9]=N[C:7]=2[O:6][CH2:5]1.[CH:13]1([C:16]2N=CC=C3C(=O)COC=23)[CH2:15][CH2:14]1>>[CH3:1][O:2][N:3]=[C:4]1[C:12]2[C:7](=[C:16]([CH:13]3[CH2:15][CH2:14]3)[N:9]=[CH:10][CH:11]=2)[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oximeHCID 867219097-cyclopropylfuro[2,3-c]pyridin-3(2H)-one

Product 1

HCID 867219107-cyclopropylfuro[2,3-c]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 7-cyclopropylfuro[2,3-c]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by CC (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as brown oil;

Workup

  1. customThis compound was prepared
  2. customPurification by CC (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-d0fc06dc03024aabaa371fa7cbb545e4
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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