m-Chloroperbenzoic acid → 3-(Methoxyimino)-2,3-dihydrofuro[2,3-c]pyridine 6-oxide

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Reaction Steps

To a solution of furo[2,3-c]pyridin-3(2H)-one O-methyl oxime (5.35 mmol) (A.2.4.4) in 15 mL DCM was added 3-chloroperbenzoic acid (16.0 mmol). The mixture was stirred at RT overnight, diluted with 20 mL DCM and extracted with sat. aq. NaHCO3 solution (2×), with sat. aq. Na2S2O3 solution (2×) and brine. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as yellow solid;

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