HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-bromo-2-chloroisonicotinate → 5-Chloro-3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-bromo-2-chloroisonicotinate | HCID 46311265 | — |
| Reactant | HCID 71239586 | HCID 71239586 | — |
| Product | 5-Chloro-3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester | HCID 86721917 | — |
Reaction Steps
This compound was prepared using a method analogous to that of 5-hydroxyfuro[2,3-c]pyridazine-6-carboxylic acid ethyl ester (A.2.3.1), 5-bromo-2-chloroisonicotinic acid ethyl ester replacing 3-chloropyridazine-4-carboxylic acid ethyl ester. Purification by CC (KP-SIL™ from Biotage) using EtOAc/MeOH (9/1) gives the desired product as brown solid;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221832B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c001c8de55c84574828bfc094f2b1271 |
| Source note | uspto-grants-2015_12 |