反应详情

温度

40 °C

To a solution of 4-bromo-2-chloronicotinic acid ethyl ester (5.06 mmol) in 15 mL MeOH was added 1.0 mL of a solution of NaOMe (30% in MeOH). The reaction mixture was stirred at 40° C. for 4 h, cooled to RT, diluted with EtOAc and then quenched with sat. aq. NH4Cl solution. The organic layers was dried over MgSO4 and concentrated in vacuo to give the desired compound as brown oil;

1. temperaturecooled to RT
2. customquenched with sat. aq. NH4Cl solution
3. dry with materialThe organic layers was dried over MgSO4
4. concentrationconcentrated in vacuo