furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime → 4-ethoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

HRID 1508252Notes

Reaction equation

HRID 1508252 reaction equation
[CH3:1][O:2][N:3]=C1C2C=CN=NC=2OC1.[CH2:13]([O:15][C:16]1[CH:21]=[C:20]([CH3:22])[N:19]=[C:18]2[O:23][CH2:24][C:25](=O)[C:17]=12)[CH3:14]>>[CH3:1][O:2][N:3]=[C:25]1[C:17]2[C:18](=[N:19][C:20]([CH3:22])=[CH:21][C:16]=2[O:15][CH2:13][CH3:14])[O:23][CH2:24]1

Participants

3

Reactant 2

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oximeHCID 867219394-ethoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one

Product 1

HCID 867219404-ethoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 4-ethoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by (KP-SIL™ from Biotage) using Hept/EtOAc (1/1) gives the desired product as white solid;

Workup

  1. customThis compound was prepared
  2. customPurification by (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-e30e0c08ec0249c4a550e97d8829d96c
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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