Sodium Methoxide → 2-Chloro-4-methoxy-6-methylnicotinic acid ethyl ester

HRID 1508254Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:16])[C:5]1[C:10]([O:11][CH2:12]C)=[CH:9][C:8]([CH3:14])=[N:7][C:6]=1[Cl:15])[CH3:2].C[O-].[Na+]>>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[C:10]([O:11][CH3:12])=[CH:9][C:8]([CH3:14])=[N:7][C:6]=1[Cl:15])[CH3:2]

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 52911135Ethyl 2-chloro-4-ethoxy-6-methylpyridine-3-carboxylate

Product 1

HCID 139336422-Chloro-4-methoxy-6-methylnicotinic acid ethyl ester

Procedure

This compound was prepared using a method analogous to that of 2-chloro-4-ethoxy-6-methylnicotinic acid ethyl ester (A.2.17.1), NaOMe replacing NaOEt;

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-b119553329394bf4bf3886ff552b17e9
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09221832B2

Reaction notes

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