furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime → 4-methoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

HRID 1508257Notes

Reaction equation

HRID 1508257 reaction equation
[CH3:1][O:2][N:3]=C1C2C=CN=NC=2OC1.[CH3:13][O:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]2[O:22][CH2:23][C:24](=O)[C:16]=12>>[CH3:1][O:2][N:3]=[C:24]1[C:16]2[C:17](=[N:18][C:19]([CH3:21])=[CH:20][C:15]=2[O:14][CH3:13])[O:22][CH2:23]1

Participants

3

Reactant 2

HCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oximeHCID 867219424-methoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one

Product 1

HCID 867219434-methoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one O-methyl oxime

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 4-methoxy-6-methylfuro[2,3-b]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by (KP-SIL™ from Biotage) using Hept/EtOAc (1/1) gives the desired product as white solid;

Workup

  1. customThis compound was prepared
  2. customPurification by (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-cd75c07d747a434399423afe680fb80d
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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