HCID 71239163, compound → HCID 86721945, compound

HRID 1508261Notes

Reaction equation

HRID 1508261 reaction equation
[CH3:1][O:2][N:3]=C1C2C=CN=NC=2OC1.[F:13][C:14]([F:26])([F:25])[C:15]1[CH:20]=[CH:19][N:18]=[C:17]2[O:21][CH2:22][C:23](=O)[C:16]=12>>[CH3:1][O:2][N:3]=[C:23]1[C:16]2[C:17](=[N:18][CH:19]=[CH:20][C:15]=2[C:14]([F:26])([F:25])[F:13])[O:21][CH2:22]1

Participants

3

Reactant 2

HCID 71239163HCID 71239163, compoundHCID 86721901furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime

Product 1

HCID 86721945HCID 86721945, compound

Procedure

This compound was prepared using a method analogous to that of furo[2,3-c]pyridazin-5(6H)-one O-methyl oxime (A.2.3.3), 4-(trifluoromethyl)furo[2,3-b]pyridin-3(2H)-one replacing furo[2,3-c]pyridazin-5(6H)-one. Purification by (KP-SIL™ from Biotage) using Hept/EtOAc (9/1) gives the desired product as colorless foam;

Workup

  1. customThis compound was prepared
  2. customPurification by (KP-SIL™ from Biotage)

Sources & evidence

ORD record
ord-4ec45f39a5b74ea5b08b46d72838bcea
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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