反应详情

An 100-mL round bottomed flask was charged with 3-chlorobenzonitrile (2.75 g, 20 mmol, 1 eq.), ethanol (1 g, 22 mmol, 1.1 eq.), HCl (4 N in dioxane, 20 ml, 80 mmol, 4 eq.). The resulting mixture was stirred at rt for 48 hr. The volatile material was removed under reduced pressure and the residue was treated ether. Solid was collected by filtration and washed with ether. The product thus obtained was forwarded to the next step without any further purification (2.87 g, 65% yield).

1. customThe volatile material was removed under reduced pressure
2. additionthe residue was treated ether
3. filtrationSolid was collected by filtration
4. washwashed with ether
5. customThe product thus obtained
6. customwas forwarded to the next step without any further purification (2.87 g, 65% yield)