Cyanamide → HCID 178512257, compound

HRID 1508700Notes

Reaction equation

HRID 1508700 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[CH:4][CH:3]=1.O(C)[Na].[NH2:12][C:13]#N.[NH4+:15].[Cl-]>CO>[Cl:1][C:2]1[S:6][C:5]([C:7](=[NH:15])[NH:8][C:13]#[N:12])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 9864CyanamideHCID 25517Ammonium ChlorideHCID 122032655-Chloro-2-thiophenecarbonitrileHCID 178418582HCID 178418582, compound

Product 1

HCID 178512257HCID 178512257, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-chlorothiophene-2-carbonitrile 1 in MeOH was added NaOCH3. The reaction mixture was stirred at room temperature for 4 h and then NH2CN was added. The reaction was allowed stir for overnight under N2. The mixture was then poured into NH4Cl (aq) and the precipitate collected and washed with water. The dried sample was confirmed as desired product 5-chloro-N-cyanothiophene-2-carboximidamide 2.

Workup

  1. stirringThe reaction was allowed stir for overnight under N2
  2. customthe precipitate collected
  3. washwashed with water

Sources & evidence

ORD record
ord-2b2e2c1a069d4abc9fd26b833e6bcf8c
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

Loading…