Ammonia → HCID 90338578, compound

HRID 1508981Notes

Reaction equation

HRID 1508981 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:21][CH2:20]3)[N:16]=[C:15]3[CH2:32][CH2:33][CH2:34][C:14]=23)=[CH:8][CH:7]=1)C.[NH3:36]>CO>[NH2:36][C:4](=[O:3])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]([CH3:29])([CH3:31])[CH3:30])=[O:26])[CH2:21][CH2:20]3)[N:16]=[C:15]3[CH2:32][CH2:33][CH2:34][C:14]=23)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 90338681HCID 90338681, compound

Product 1

HCID 90338578HCID 90338578, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following general procedure C, tert-butyl 4-(4-((4-(2-ethoxy-2-oxoethyl)phenyl)amino)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)piperazine-1-carboxylate (0.034 g, 0.071 mmol) was reacted with ammonia in methanol (7.0 M, 5 mL) to afford crude product (0.031 g) as an orange oil. MW=451.56. APCI MS m/z 452 [M+H]+.

Sources & evidence

ORD record
ord-b36655e995b04a4c8a34c2b51d305ea5
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

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