HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → tert-butyl(1-(4-(1-(2-cyanoethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromopropionitrile | HCID 17020 | — |
| Reactant | HCID 67256382 | HCID 67256382 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl(1-(4-(1-(2-cyanoethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate | HCID 123769430 | — |
Reaction Steps
A mixture of tert-butyl 1-(4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate (100 mg, 0.212 mmol), 3-bromopropanenitrile (85 mg, 0.636 mmol) and potassium carbonate (88 mg) in DMF (4 ml) was heated at 80 degree for 16 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09221838B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-1555fe4fb0da43ab8a2f5255244d3ad5 |
| Source note | uspto-grants-2015_12 |