Potassium Carbonate → HCID 123769430, compound

HRID 1509179Notes

Reaction equation

HRID 1509179 reaction equation
[O:1]=[C:2]1[CH2:7][O:6][C:5]2[N:8]=[C:9]([C:18]3[CH:23]=[CH:22][C:21]([C:24]4([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH2:27][CH2:26][CH2:25]4)=[CH:20][CH:19]=3)[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:11][C:4]=2[NH:3]1.Br[CH2:37][CH2:38][C:39]#[N:40].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:31]([O:30][C:29](=[O:35])[NH:28][C:24]1([C:21]2[CH:22]=[CH:23][C:18]([C:9]3[C:10]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[CH:11][C:4]4[N:3]([CH2:37][CH2:38][C:39]#[N:40])[C:2](=[O:1])[CH2:7][O:6][C:5]=4[N:8]=3)=[CH:19][CH:20]=2)[CH2:25][CH2:26][CH2:27]1)([CH3:32])([CH3:34])[CH3:33]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 170203-BromopropionitrileHCID 67256382HCID 67256382, compound

Product 1

HCID 123769430HCID 123769430, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of tert-butyl 1-(4-(2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate (100 mg, 0.212 mmol), 3-bromopropanenitrile (85 mg, 0.636 mmol) and potassium carbonate (88 mg) in DMF (4 ml) was heated at 80 degree for 16 h.

Workup

  1. temperaturewas heated at 80 degree for 16 h.

Sources & evidence

ORD record
ord-1555fe4fb0da43ab8a2f5255244d3ad5
Source dataset
uspto-grants-2015_12
Patent number
US09221838B2

Reaction notes

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