Hydrazine hydrate (1:1) → 3,3,3-Trifluoropropanehydrazide

HRID 1509282Notes

Reaction equation

HRID 1509282 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]([F:9])([F:8])[F:7])C.O.[NH2:12][NH2:13]>>[F:7][C:6]([F:9])([F:8])[CH2:5][C:4]([NH:12][NH2:13])=[O:3]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2782349Ethyl 3,3,3-Trifluoropropionate

Product 1

HCID 167866073,3,3-Trifluoropropanehydrazide

Procedure

Ethyl-3,3,3-trifluoropropanoate (2.5 g, 0.016 mol) and hydrazine monohydrate (1.2 g, 0.024 mol) were heated to reflux for 1 hour. The reaction mixture was concentrated under reduced pressure and the residue was treated with toluene (100 ml×3) to azeotrope hydrazine in excess.

Workup

  1. temperatureto reflux for 1 hour
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionthe residue was treated with toluene (100 ml×3)

Sources & evidence

ORD record
ord-aca1205241fd4feeaa53a38ef6fa6f3a
Source dataset
uspto-grants-2015_12
Patent number
US09221838B2

Reaction notes

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