Phosphoric Acid → HCID 117951820, compound

HRID 1509371Notes

Reaction equation

HRID 1509371 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[C:11]([NH:23][C:24]([C:26]2[CH:31]=[CH:30][C:29]([CH2:32][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)=[CH:28][CH:27]=2)=[O:25])[C:12]([NH:14][CH2:15][CH2:16][CH2:17][CH:18](OC)[O:19]C)=[O:13])=[CH:6][CH:5]=1)=[N+:2]=[N-:3].P(=O)(O)(O)O>O>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]=[C:11]([NH:23][C:24]([C:26]2[CH:27]=[CH:28][C:29]([CH2:32][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)=[CH:30][CH:31]=2)=[O:25])[C:12]([NH:14][CH2:15][CH2:16][CH2:17][CH:18]=[O:19])=[O:13])=[CH:8][CH:9]=1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 131734409HCID 131734409, compound

Product 1

HCID 117951820HCID 117951820, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound produced in Example 2 [photosensitive material C] (2 g) was added to a mixture of water (40 g) and phosphoric acid (0.5 g), and the resultant mixture was stirred at 20° C. for 5 hours, to thereby remove the acetal protective group. Thereafter, the temperature of the deprotected mixture was adjusted to 10° C. and neutralized with 1 weight % aqueous sodium hydroxide to a pH of 8. The precipitates formed through neutralization were immediately separated through filtration and dried, to thereby yield 1 g of photosensitive material F as a target compound.

Workup

  1. customto thereby remove the acetal protective group
  2. customwas adjusted to 10° C. and neutralized with 1 weight % aqueous sodium hydroxide to a pH of 8
  3. customThe precipitates formed through neutralization
  4. customwere immediately separated through filtration
  5. customdried

Sources & evidence

ORD record
ord-b65be25bb86240f584150874b0a3397c
Source dataset
uspto-grants-2015_12
Patent number
US09223210B2

Reaction notes

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