Potassium Acetate → HCID 58355527, compound

HRID 1509547Notes

Reaction equation

HRID 1509547 reaction equation
Cl[C:2]1[N:3]=[C:4]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[N:5]([CH2:35][CH2:36][CH2:37][CH2:38][O:39][CH3:40])[C:6]=1[C:7]([N:9]([CH2:31][CH:32]([CH3:34])[CH3:33])[C@H:10]1[CH2:15][C@@H:14]([C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:17])[CH2:13][N:12]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:11]1)=[O:8].C([O-])(=O)C.[K+]>CO.[OH-].[Pd+2].[OH-].[C]>[CH3:40][O:39][CH2:38][CH2:37][CH2:36][CH2:35][N:5]1[C:6]([C:7]([N:9]([CH2:31][CH:32]([CH3:33])[CH3:34])[C@H:10]2[CH2:15][C@@H:14]([C:16]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)=[O:17])[CH2:13][N:12]([C:24]([O:26][C:27]([CH3:30])([CH3:28])[CH3:29])=[O:25])[CH2:11]2)=[O:8])=[CH:2][N:3]=[C:4]1[C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1

Participants

5

Reactant 2

HCID 517044Potassium AcetateHCID 58355151HCID 58355151, compound

Product 1

HCID 58355527HCID 58355527, compoundYield 47.5%

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 887MethanolSolvent

Procedure

tert-Butyl (3S,5R)-3-[{[4-chloro-1-(4-methoxybutyl)-2-phenyl-1H-imidazol-5-yl]carbonyl}(2-methylpropyl)amino]-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (200 mg), palladium(II) hydroxide-carbon (20 mg) and potassium acetate (30 mg) were suspended in methanol (10 ml), and the mixture was stirred under a hydrogen atmosphere (1 atom) at room temperature for 1 day. The palladium catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was suspended in water, and the suspension was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography, and a fraction eluted with ethyl acetate-hexane (10:90-80:20) was concentrated under reduced pressure to give the object product (90 mg).

Workup

  1. filtrationThe palladium catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. extractionthe suspension was extracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. washa fraction eluted with ethyl acetate-hexane (10:90-80:20)
  8. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-8a53750ea4304399b0223837e11911ac
Source dataset
uspto-grants-2015_12
Patent number
US09221836B2

Reaction notes

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