反应详情

Methyl 5-(4-methoxybutyl)-2-methyl-1-phenyl-1H-imidazole-4-carboxylate (3.85 g) was dissolved in methanol (26 ml)-water (24 ml), lithium hydroxide monohydrate (800 mg) was added and the mixture was heated under reflux for 2 hr. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was adjusted to pH=7 with 1M hydrochloric acid, subjected to DIAION HP-20 (manufactured by Mitsubishi Chemical), washed with water and a fraction eluted with acetone was concentrated under reduced pressure to give the object product (1.08 g).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 hr
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. washwashed with water
6. washa fraction eluted with acetone
7. concentrationwas concentrated under reduced pressure