Hydrogen chloride-ethyl acetate → HCID 67321216, compound

HRID 1509609Notes

Reaction equation

HRID 1509609 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:10]=[N:9][C:8]=1[C:18]([N:20]([CH2:41][CH:42]([CH3:44])[CH3:43])[C@H:21]1[CH2:26][C@@H:25]([C:27]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:28])[CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22]1)=[O:19].C(OCC)(=O)C.[ClH:51]>C(OCC)(=O)C>[ClH:51].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:11]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:10]=[N:9][C:8]=1[C:18]([N:20]([CH2:41][CH:42]([CH3:44])[CH3:43])[C@H:21]1[CH2:26][C@@H:25]([C:27]([N:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)=[O:28])[CH2:24][NH:23][CH2:22]1)=[O:19]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58355108HCID 58355108, compound

Product 1

HCID 67321216HCID 67321216, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl (3S,5R)-3-[{[5-(4-methoxybutyl)-1-phenyl-1H-1,2,3-triazol-4-yl]carbonyl}(2-methylpropyl)amino]-5-(pyrrolidin-1-ylcarbonyl)piperidine-1-carboxylate (245 mg) was dissolved in ethyl acetate (0.5 ml), 4N hydrogen chloride-ethyl acetate solution (0.5 ml) was added, and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was dried under reduced pressure to give the object product (205 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-4d10b17a34954c4393707d5cca3c0a53
Source dataset
uspto-grants-2015_12
Patent number
US09221836B2

Reaction notes

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