Hydrochloric Acid → HCID 178494463, compound

HRID 1509724Notes

Reaction equation

HRID 1509724 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@H:6]([C:10]([N:12]1[CH2:16][CH:15]([CH2:17][O:18][CH3:19])[CH2:14][CH:13]1[C:20]1[NH:24][C:23]2[C:25]3[C:30]([CH:31]=[CH:32][C:22]=2[N:21]=1)=[CH:29][C:28]1[C:33]2[C:38]([CH2:39][O:40][C:27]=1[CH:26]=3)=[CH:37][C:36]([C:41]1[NH:45][C:44]([CH:46]3[CH2:50][CH:49]([CH3:51])[CH2:48][N:47]3C(OC(C)(C)C)=O)=[N:43][CH:42]=1)=[CH:35][CH:34]=2)=[O:11])[CH:7]([CH3:9])[CH3:8])=[O:4].Cl>C(O)C>[CH3:19][O:18][CH2:17][CH:15]1[CH2:16][N:12]([C:10](=[O:11])[CH:6]([NH:5][C:3](=[O:4])[O:2][CH3:1])[CH:7]([CH3:9])[CH3:8])[CH:13]([C:20]2[NH:24][C:23]3[C:25]4[C:30]([CH:31]=[CH:32][C:22]=3[N:21]=2)=[CH:29][C:28]2[C:33]3[C:38]([CH2:39][O:40][C:27]=2[CH:26]=4)=[CH:37][C:36]([C:41]2[NH:45][C:44]([CH:46]4[CH2:50][CH:49]([CH3:51])[CH2:48][NH:47]4)=[N:43][CH:42]=2)=[CH:35][CH:34]=3)[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178494461HCID 178494461, compound

Product 1

HCID 178494463HCID 178494463, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-butyl 2-[5-(2-{1-[N-(methoxycarbonyl)valyl]-4-(methoxymethyl)pyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carboxylate (50 mg, 0.063 mmol) was treated with 2 mL 1.25N HCl in ethanol and heated at 60° C. for 2h, then it was concentrated under reduced pressure and pumped dry under high vacuum and used directly in the next step.

Workup

  1. concentrationit was concentrated under reduced pressure
  2. custompumped dry under high vacuum

Sources & evidence

ORD record
ord-b8b3147148524c37afdcb0503a05fe0b
Source dataset
uspto-grants-2015_12
Patent number
US09221833B2

Reaction notes

Loading…