5-Aminosalicylic Acid → HCID 9856513, compound

HRID 1509816Notes

Reaction equation

HRID 1509816 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 680214-Fluorobenzyl bromide

Product 1

HCID 9856513HCID 9856513, compoundYield 56.4%

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-fluorobenzyl bromide (740 mg, 3.92 mmole), 480 mg (44% yield) of 5-(4-fluorobenzyl)aminosalicylic acid was obtained as a white solid.:mp>210° C. (decompose).

Workup

  1. customin Synthesis Example 1

Sources & evidence

ORD record
ord-507ab35cf91a44c6a2cb0a9784f3d658
Source dataset
uspto-grants-2012_07
Patent number
US08211877B2

Reaction notes

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