反应详情

温度

130 °C

103.5 g of methyl 3-[5-(dimethylaminomethylenamino)pyrimidin-2-yl]benzoate (364.04 mmol) are suspended in 1300 ml of water in a 2 l single-necked flask, and 160 ml of conc. sulfuric acid (95-97%) (2.88 mol) are subsequently added, and the reaction batch is warmed at 130° C. (oil-bath temperature) for 4 h. For work-up, the reaction batch is cooled, and the precipitate formed is filtered off, washed with water and dried at 50° C. in a vacuum drying cabinet.

1. temperatureFor work-up, the reaction batch is cooled
2. customthe precipitate formed
3. filtrationis filtered off
4. washwashed with water
5. customdried at 50° C. in a vacuum
6. customdrying cabinet