Sulfuric Acid → 3-(5-Hydroxypyrimidin-2-yl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

103.5 g of methyl 3-[5-(dimethylaminomethylenamino)pyrimidin-2-yl]benzoate (364.04 mmol) are suspended in 1300 ml of water in a 2 l single-necked flask, and 160 ml of conc. sulfuric acid (95-97%) (2.88 mol) are subsequently added, and the reaction batch is warmed at 130° C. (oil-bath temperature) for 4 h. For work-up, the reaction batch is cooled, and the precipitate formed is filtered off, washed with water and dried at 50° C. in a vacuum drying cabinet.

Provenance & Evidence