4-Fluorobenzene-1,2-diamine → HCID 59590554, compound

HRID 1509998Notes

Reaction equation

HRID 1509998 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][N:4]=1)#[N:2].[F:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[C:15]([NH2:20])[CH:14]=1>>[NH2:2][CH2:1][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:19][C:16]2[CH:17]=[CH:18][C:13]([F:12])=[CH:14][C:15]=2[NH2:20])=[O:9])=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 1645844-Fluorobenzene-1,2-diamineHCID 27611086-Cyanopyridine-3-carboxylic acid

Product 1

HCID 59590554HCID 59590554, compoundYield 52%

Procedure

The title compound (135 mg, 52% yield) was prepared as a grey solid from 6-cyano-nicotinic acid (296 mg, 2 mmol) and 4-fluoro-o-phenylenediamine (302 mg, 2.4 mmol) by an analogous procedure to that described in example 8. LC-MS (m/z) 261 (M+1).

Sources & evidence

ORD record
ord-a99dc2df0496466f9af333d56fc52faf
Source dataset
uspto-grants-2012_07
Patent number
US08211901B2

Reaction notes

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