HRID1510011

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2ncnc(Oc3ccc4c(C(=O)O)cccc4c3)c2cc1OC

HCID24823734

未命名化合物

结构：NCc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2N)cc1

HCID59590543

未命名化合物

PRODUCTS

生成物

结构：COc1cc2ncnc(Oc3ccc4c(C(=O)NCc5ccc(C(=O)Nc6ccc(C(F)(F)F)cc6N)cc5)cccc4c3)c2cc1OC

HCID49805385

未命名化合物

收率 70%

PROCEDURE

实验过程

The title compound (46.7 mg, 70% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthoic acid (37.6 mg, 0.1 mmol) and 4-(aminomethyl)-N-(2-amino-4-trifluoromethylphenyl)benzamide (37.1 mg, 0.12 mmol) by an analogous procedure to that described in example 16. LC-MS (m/z) 668 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d7e8ca6abdb46a6aa4c6731fa584a5a
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08211901B2
来源说明: uspto-grants-2012_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[O:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22]([C:26](O)=[O:27])=[CH:21][CH:20]=[CH:19]2.[NH2:29][CH2:30][C:31]1[CH:50]=[CH:49][C:34]([C:35]([NH:37][C:38]2[CH:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][C:39]=2[NH2:48])=[O:36])=[CH:33][CH:32]=1>>[NH2:48][C:39]1[CH:40]=[C:41]([C:44]([F:46])([F:47])[F:45])[CH:42]=[CH:43][C:38]=1[NH:37][C:35]([C:34]1[CH:49]=[CH:50][C:31]([CH2:30][NH:29][C:26]([C:22]2[C:23]3[C:18](=[CH:17][C:16]([O:15][C:6]4[C:5]5[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=5)[N:9]=[CH:8][N:7]=4)=[CH:25][CH:24]=3)[CH:19]=[CH:20][CH:21]=2)=[O:27])=[CH:32][CH:33]=1)=[O:36]