HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acid → N-(4-((2-amino-4-trifluoromethylphenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(6,7-Dimethoxyquinazolin-4-yloxy)-1-naphthoic acid | HCID 24823734 | — |
| Reactant | 4-(aminomethyl)-N-(2-amino-4-trifluoromethylphenyl)benzamide | HCID 59590543 | — |
| Product | N-(4-((2-amino-4-trifluoromethylphenyl)carbamoyl)benzyl)-6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthamide | HCID 49805385 | 70% |
Reaction Steps
The title compound (46.7 mg, 70% yield) was prepared as a brown solid from 6-(6,7-dimethoxyquinazolin-4-yloxy)-1-naphthoic acid (37.6 mg, 0.1 mmol) and 4-(aminomethyl)-N-(2-amino-4-trifluoromethylphenyl)benzamide (37.1 mg, 0.12 mmol) by an analogous procedure to that described in example 16. LC-MS (m/z) 668 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211901B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-3d7e8ca6abdb46a6aa4c6731fa584a5a |
| Source note | uspto-grants-2012_07 |