O-Cresol → HCID 66920347, compound

HRID 1510067Notes

Reaction equation

HRID 1510067 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH3:26])=[CH:22][CH:23]=3)[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2Cl)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[OH:41]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][C:21]([O:25][CH3:26])=[CH:22][CH:23]=3)[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[O:41][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[CH3:34])=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 335O-CresolHCID 669204554-(2-Chloro-6-methoxy-1-phenyl-1h-indole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 66920347HCID 66920347, compound

Procedure

From the compound of step 4, the title compound was prepared analogously as described in example 1, step 2, using 2-methylphenol. Yield: 480 mg.

Sources & evidence

ORD record
ord-5800c42405d04247bbf1a43dfbd1c664
Source dataset
uspto-grants-2012_07
Patent number
US08211885B2

Reaction notes

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