反应详情

A combination of 32 g (268 mmol, Aldrich) 3-cyanophenol, 26.9 mL (268 mmol) 2-iodopropane, and 88 g (269 mmol) cesium carbonate in 1:1 CH2Cl2:CH3CN was heated to reflux and allowed to stir overnight. HPLC/MS showed pure product so the suspension was filtered, washed with CH3CN and concentrated. The remaining oil was dissolved in CH2Cl2 and filtered thru a short pad of silica with CH2Cl2. The filtrate was concentrated to dryness to give the product. An alternative preparation uses the conditions similar to the above except that potassium carbonate is used as the base.

1. temperatureto reflux
2. filtrationwas filtered
3. washwashed with CH3CN
4. concentrationconcentrated
5. dissolutionThe remaining oil was dissolved in CH2Cl2
6. filtrationfiltered
7. concentrationThe filtrate was concentrated to dryness
8. customto give the product
9. customAn alternative preparation