反应详情

温度

50 °C

To a solution of methyl 3-(cyclopropylmethyl)benzoate (9.06 g, 47.6 mmol) in THF (100 mL) was added lithium borohydride (2.0 M in THF, 71.4 mL, 142.9 mmol). After stirring at 50° C. for 1 h the reaction was cooled, quenched with excess methanol and concentrated under vacuum. Purification by silica gel chromatography (30% EtOAc/hexanes) afforded the desired product.

1. temperaturewas cooled
2. customquenched with excess methanol
3. concentrationconcentrated under vacuum
4. customPurification by silica gel chromatography (30% EtOAc/hexanes)