反应详情

温度

80 °C

To a solution of methyl 1H-indole-6-carboxylate (5.00 g, 28.5 mmol) and cesium carbonate (18.6 g, 57.1 mmol) in DMPU (50 mL) was added 2-iodopropane (3.71 mL, 37.1 mmol). After stirring at 80° C. for 4 h, the solution was cooled to rt, poured onto ether, washed with H2O (three times) and brine, dried with Na2SO4, and concentrated. The crude compound was chromatographed to give the desired product. LCMS (M+1)=218.1

1. temperaturethe solution was cooled to rt
2. additionpoured onto ether
3. washwashed with H2O (three times) and brine
4. dry with materialdried with Na2SO4
5. concentrationconcentrated
6. customThe crude compound was chromatographed