Hydrazine → HCID 68081121, compound

HRID 1510140Notes

Reaction equation

HRID 1510140 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@H:9]2[CH2:13][CH2:12][CH2:11][C@H:10]2[N:14]2C(=O)C3C(=CC=CC=3)C2=O)[CH:6]=[CH:7][CH:8]=1.NN>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@H:9]2[CH2:13][CH2:12][CH2:11][C@H:10]2[NH2:14])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86610166HCID 86610166, compound

Product 1

HCID 68081121HCID 68081121, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of cis 2-[2-(3-methoxyphenyl)cyclopentyl]-1H-isoindole-1,3(2H)-dione (0.23 g, 0.72 mmol) in toluene (3 mL) was added hydrazine (0.23 mL, 7.23 mmol). After stirring at room temperature for 1 h, then 95° C. for 4 h, a precipitate formed. The mixture was cooled to rt, filtered, and washed with toluene. The filtrate was concentrated to give the desired product, which was used without further purification.

Workup

  1. wait95° C. for 4 h
  2. customa precipitate formed
  3. temperatureThe mixture was cooled to rt
  4. filtrationfiltered
  5. washwashed with toluene
  6. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-f4f22a953ee44751b61f550d9dcc52ea
Source dataset
uspto-grants-2012_07
Patent number
US08211904B2

Reaction notes

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